| A'Shawn Robinson | DT | | Did Not Participate In Practice | |
| Aaron Banks | G | Knee | Limited Participation in Practice | Questionable |
| Aaron Donald | DT | | Did Not Participate In Practice | |
| Aidan O'Connell | QB | Not injury related - personal matter | Did Not Participate In Practice | Questionable |
| Ajani Cornelius | T | | Full Participation in Practice | |
| Akeem Davis-Gaither | LB | | Full Participation in Practice | |
| Akheem Mesidor | DE | | Full Participation in Practice | |
| Alaric Jackson | T | | Did Not Participate In Practice | |
| Alec Pierce | WR | | Full Participation in Practice | |
| Alvin Kamara | RB | | Full Participation in Practice | |
| Andrew Mukuba | S | Knee | Limited Participation in Practice | Questionable |
| Andrew Thomas | T | | Limited Participation in Practice | |
| Andrew Van Ginkel | LB | | Full Participation in Practice | |
| Anthony Richardson | QB | | Full Participation in Practice | |
| Ashton Dulin | WR | Ankle | Did Not Participate In Practice | Out |
| Ashton Gillotte | DE | | Full Participation in Practice | |
| Ashton Jeanty | RB | | Full Participation in Practice | |
| Austin Ajiake | LB | | Full Participation in Practice | |
| B.J. Hill | DT | Achilles | Did Not Participate In Practice | Questionable |
| Barryn Sorrell | LB | | Limited Participation in Practice | |
| Ben Brown | C | Knee | Limited Participation in Practice | Questionable |
| Benjamin St-Juste | CB | Hamstring | Limited Participation in Practice | Questionable |
| Blake Cashman | LB | | Full Participation in Practice | |
| Blake Miller | T | Knee | Did Not Participate In Practice | Out |
| Bradley Chubb | LB | | Full Participation in Practice | |
| Brandon Cisse | CB | | Full Participation in Practice | |
| Brian O'Neill | T | Knee | Limited Participation in Practice | Questionable |
| Brian Thomas Jr. | WR | | Limited Participation in Practice | |
| Brock Bowers | TE | Knee | Limited Participation in Practice | Doubtful |
| Bud Dupree | DE | | Full Participation in Practice | |
| Byron Young | LB | | Did Not Participate In Practice | |
| Calais Campbell | DT | | Full Participation in Practice | |
| Cameron Heyward | DT | | Full Participation in Practice | |
| Cameron Jordan | LB | | Full Participation in Practice | |
| Carlton Davis III | CB | Neck | Did Not Participate In Practice | Out |
| Cedric Gray | LB | Concussion | Full Participation in Practice | Questionable |
| Chamarri Conner | S | Knee | Did Not Participate In Practice | Out |
| Charles Omenihu | DE | | Limited Participation in Practice | |
| Charvarius Ward | CB | | Did Not Participate In Practice | |
| Chase Young | LB | Calf | Limited Participation in Practice | Questionable |
| Chauncey Golston | DE | | Full Participation in Practice | |
| Chig Okonkwo | TE | Hamstring | Did Not Participate In Practice | Out |
| Chop Robinson | LB | Concussion | Did Not Participate In Practice | Out |
| Chris Jones | DT | Calf | Limited Participation in Practice | Questionable |
| Chris Olave | WR | Hamstring | Limited Participation in Practice | Questionable |
| Chris Paul | G | | Full Participation in Practice | |
| Christen Miller | DT | Toe | Limited Participation in Practice | Questionable |
| Christian Braswell | CB | | Full Participation in Practice | |
| Christian Darrisaw | T | | Did Not Participate In Practice | |
| Christian Izien | S | | Full Participation in Practice | |
| Christian Mahogany | G | Hip | Did Not Participate In Practice | Out |
| Christian McCaffrey | RB | | Full Participation in Practice | |
| Christian Rozeboom | LB | | Full Participation in Practice | |
| Cole Bishop | S | Knee, Groin | Limited Participation in Practice | Questionable |
| Cole Van Lanen | T | | Full Participation in Practice | |
| Cooper DeJean | CB | | Full Participation in Practice | |
| Cordale Flott | CB | Quadricep | Did Not Participate In Practice | Questionable |
| D'Andre Swift | RB | | Full Participation in Practice | |
| D'Angelo Ponds | CB | | Full Participation in Practice | |
| D.J. Reed | CB | Foot | Limited Participation in Practice | Questionable |
| DJ Giddens | RB | Knee | Full Participation in Practice | Questionable |
| Dalton Schultz | TE | | Did Not Participate In Practice | |
| Dalvin Tomlinson | DT | | Full Participation in Practice | |
| Dametrious Crownover | T | Knee | Did Not Participate In Practice | Out |
| Dante Trader Jr. | S | | Full Participation in Practice | |
| Darien Porter | CB | Foot | Did Not Participate In Practice | Out |
| Darnell Washington | TE | | Full Participation in Practice | |
| Darnell Wright | T | | Full Participation in Practice | |
| Daron Payne | DT | | Full Participation in Practice | |
| Davante Adams | WR | | Full Participation in Practice | |
| David Onyemata | DT | | Full Participation in Practice | |
| Davon Godchaux | DT | | Full Participation in Practice | |
| Dawand Jones | T | | Full Participation in Practice | |
| Daxton Hill | CB | | Full Participation in Practice | |
| Dayo Odeyingbo | DE | | Full Participation in Practice | |
| De'Zhaun Stribling | WR | Ankle | Did Not Participate In Practice | Out |
| DeForest Buckner | DT | | Did Not Participate In Practice | |
| DeMarvion Overshown | LB | Hamstring | Did Not Participate In Practice | Out |
| Deane Leonard | CB | Abdomen | Limited Participation in Practice | Questionable |
| Deonte Banks | CB | Calf | Did Not Participate In Practice | Questionable |
| Derius Davis | WR | | Full Participation in Practice | |
| Devonte Wyatt | DT | | Limited Participation in Practice | |
| Devontez Walker | WR | | Full Participation in Practice | |
| Dexter Lawrence | DT | | Did Not Participate In Practice | |
| Dorance Armstrong | LB | | Limited Participation in Practice | |
| Dre Greenlaw | LB | | Full Participation in Practice | |
| Dre'Mont Jones | LB | Foot | Limited Participation in Practice | Questionable |
| Ed Ingram | G | Groin | Did Not Participate In Practice | Out |
| Eddy Pineiro | K | Illness | Did Not Participate In Practice | Questionable |
| Elgton Jenkins | C | | Full Participation in Practice | |
| Elijah Molden | S | Hamstring | Did Not Participate In Practice | Out |
| Elijah Moore | WR | | Full Participation in Practice | |
| Foye Oluokun | LB | | Full Participation in Practice | |
| Francis Mauigoa | T | | Full Participation in Practice | |
| Frankie Luvu | LB | Groin | Did Not Participate In Practice | Out |
| George Kittle | TE | | Full Participation in Practice | |
| Grady Jarrett | DT | | Full Participation in Practice | |
| Greg Newsome II | CB | | Full Participation in Practice | |
| Grover Stewart | DT | | Full Participation in Practice | |
| Harrison Smith | S | | Limited Participation in Practice | |
| Isaiah Stalbird | LB | Shoulder | Did Not Participate In Practice | Doubtful |
| Jacob Hummel | LB | Groin | Did Not Participate In Practice | Out |
| Jacob Parrish | CB | Back | Full Participation in Practice | Questionable |
| Jadeveon Clowney | DE | Knee | Did Not Participate In Practice | Out |
| Jakobi Meyers | WR | | Limited Participation in Practice | |
| Jalen Carter | DT | | Limited Participation in Practice | |
| Jalen McMillan | WR | Knee | Full Participation in Practice | Questionable |
| James Houston | LB | | Full Participation in Practice | |
| James Williams | LB | Elbow | Limited Participation in Practice | Questionable |
| Jamien Sherwood | LB | | Full Participation in Practice | |
| Jarvis Brownlee Jr. | CB | | Full Participation in Practice | |
| Jauan Jennings | WR | Not injury related - personal matter | Did Not Participate In Practice | Out |
| Javon Hargrave | DT | Knee, Concussion | Did Not Participate In Practice | Doubtful |
| Javon Kinlaw | DT | Back | Limited Participation in Practice | Questionable |
| Jaylin Lane | WR | | Limited Participation in Practice | |
| Jaylinn Hawkins | S | | Full Participation in Practice | |
| Jerry Jeudy | WR | | Full Participation in Practice | |
| Joe Burrow | QB | Back | Full Participation in Practice | Questionable |
| Joe Thuney | G | | Full Participation in Practice | |
| Joey Porter Jr. | CB | Back | Limited Participation in Practice | Out |
| John Simpson | G | Groin | Limited Participation in Practice | Questionable |
| Jonah Elliss | LB | | Full Participation in Practice | |
| Jonathan Allen | DT | | Full Participation in Practice | |
| Jonathan Greenard | LB | Pectoral | Limited Participation in Practice | Out |
| Jordan Hancock | CB | | Full Participation in Practice | |
| Jordan Whittington | WR | Quadricep | Did Not Participate In Practice | Doubtful |
| Joseph Ossai | DE | Foot | Did Not Participate In Practice | Out |
| Josh Simmons | T | Back | Did Not Participate In Practice | Out |
| Juice Scruggs | G | | Full Participation in Practice | |
| Justin Skule | T | | Full Participation in Practice | |
| Juwan Johnson | TE | | Full Participation in Practice | |
| K'Lavon Chaisson | LB | | Limited Participation in Practice | |
| Kaelon Black | RB | Groin | Limited Participation in Practice | Questionable |
| Kam Curl | S | | Limited Participation in Practice | |
| Kamren Kinchens | S | Hamstring | Did Not Participate In Practice | Out |
| Kaytron Allen | RB | | Full Participation in Practice | |
| Keenan Allen | WR | | Full Participation in Practice | |
| Keion White | DE | | Full Participation in Practice | |
| Kene Nwangwu | RB | Back | Did Not Participate In Practice | Out |
| Keondre Jackson | S | | Full Participation in Practice | |
| Khalid Kareem | DE | | Full Participation in Practice | |
| Khalil Mack | DE | | Full Participation in Practice | |
| Kyle Juszczyk | FB | | Full Participation in Practice | |
| Kyle Monangai | RB | | Full Participation in Practice | |
| Kyler Murray | QB | Concussion | Limited Participation in Practice | Out |
| L'Jarius Sneed | CB | | Full Participation in Practice | |
| Ladd McConkey | WR | Rib | Limited Participation in Practice | Questionable |
| LeQuint Allen Jr. | RB | | Limited Participation in Practice | |
| Logan Hall | DE | | Did Not Participate In Practice | |
| Lukas Van Ness | LB | Concussion | Limited Participation in Practice | Questionable |
| Maliek Collins | DT | | Limited Participation in Practice | |
| Malik Hooker | S | Forearm | Did Not Participate In Practice | Out |
| Malik Muhammad | CB | | Full Participation in Practice | |
| Malik Willis | QB | | Full Participation in Practice | |
| Mansoor Delane | CB | Shoulder | Limited Participation in Practice | Questionable |
| Marquise Brown | WR | | Full Participation in Practice | |
| Marvin Mims Jr. | WR | Foot | Did Not Participate In Practice | Out |
| Micah McFadden | LB | Neck | Limited Participation in Practice | Questionable |
| Michael Pittman | WR | Foot | Did Not Participate In Practice | Questionable |
| Miles Killebrew | S | Concussion | Full Participation in Practice | Questionable |
| Minkah Fitzpatrick | S | Groin | Did Not Participate In Practice | Out |
| Nate Landman | LB | | Limited Participation in Practice | |
| Neville Gallimore | DT | | Full Participation in Practice | |
| Nick Bosa | DE | | Full Participation in Practice | |
| Nico Collins | WR | Hamstring | Did Not Participate In Practice | Out |
| Nnamdi Madubuike | DT | Neck | Limited Participation in Practice | Out |
| Noah Igbinoghene | CB | Hand | | Questionable |
| Odafe Oweh | LB | | Limited Participation in Practice | |
| Omar Cooper Jr. | WR | Ankle | Did Not Participate In Practice | Out |
| Omar Speights | LB | | Full Participation in Practice | |
| Oscar Delp | TE | | Full Participation in Practice | |
| Ozzy Trapilo | T | | Full Participation in Practice | |
| Parker Brailsford | C | | Full Participation in Practice | |
| Patrick Mahomes | QB | | Full Participation in Practice | |
| Paulson Adebo | CB | | Did Not Participate In Practice | |
| Puka Nacua | WR | Hip | Did Not Participate In Practice | Questionable |
| R Mason Thomas | DE | | Full Participation in Practice | |
| RJ Harvey | RB | Hamstring | Limited Participation in Practice | Questionable |
| Rashee Rice | WR | | Full Participation in Practice | |
| Robert Spillane | LB | | Full Participation in Practice | |
| Ronnie Harrison | LB | Hamstring | Did Not Participate In Practice | Out |
| Ronnie Stanley | T | Toe | Limited Participation in Practice | Questionable |
| Samaje Perine | RB | | Did Not Participate In Practice | |
| Sauce Gardner | CB | | Full Participation in Practice | |
| Sean Tucker | RB | | Full Participation in Practice | |
| Seydou Traore | TE | | Limited Participation in Practice | |
| Shemar Stewart | DE | | Full Participation in Practice | |
| T.J. Sanders | DE | Knee, Illness | Limited Participation in Practice | Questionable |
| T.J. Tampa | CB | Knee | Did Not Participate In Practice | Out |
| Teair Tart | DT | | Full Participation in Practice | |
| Teddye Buchanan | LB | Knee | Limited Participation in Practice | Out |
| Terrel Bernard | LB | | Limited Participation in Practice | |
| Teven Jenkins | G | Back | Did Not Participate In Practice | Out |
| TreVeyon Henderson | RB | | Full Participation in Practice | |
| Trent Brown | T | | Full Participation in Practice | |
| Trent Williams | T | | Full Participation in Practice | |
| Trey Hendrickson | LB | Finger | Limited Participation in Practice | Questionable |
| Trey Pipkins | T | Knee | Did Not Participate In Practice | Out |
| Troy Fautanu | T | Ankle | Full Participation in Practice | Questionable |
| Troy Franklin | WR | | Full Participation in Practice | |
| Tucker Addington | LS | Shoulder | Limited Participation in Practice | Questionable |
| Ty Johnson | RB | Hamstring | Limited Participation in Practice | Questionable |
| Ty'Ron Hopper | LB | | Limited Participation in Practice | |
| Tyler Higbee | TE | | Did Not Participate In Practice | |
| Tyler Owens | S | | Full Participation in Practice | |
| Tyson Campbell | CB | Ankle | Limited Participation in Practice | Questionable |
| Upton Stout | CB | | Full Participation in Practice | |
| Wade Woodaz | LB | | Full Participation in Practice | |
| Warren Brinson | DT | Calf | Did Not Participate In Practice | Out |
| Will Anderson Jr. | DE | | Limited Participation in Practice | |
| Will McDonald IV | DE | Ankle | Limited Participation in Practice | Questionable |
| Xavier Woods | S | | Full Participation in Practice | |
| Zach Bako-Bewele | T | Knee | Limited Participation in Practice | Questionable |
| Zach Wood | LS | Calf | Did Not Participate In Practice | Out |
| Zay Flowers | WR | Hamstring | Limited Participation in Practice | Doubtful |
| Zion Johnson | G | | Full Participation in Practice | |